by targeting the protein surface, active site, predicted epitopes, hydrophobic patches and so on). Such beneficial amino acid diversity is then iteratively recombined, while the introduction of ...

Protein improvement strategies today involve ... A survey of single–amino acid substitutions found that substitutions closer to the active site give larger improvements in enantioselectivity ...

Whatever the assailant, though, snake-bite treatment has been the same for a century: inject an antivenin containing ...

showing that the E1 active site is uniquely remodeled to promote adenylation and thioester bond formation. We also determined the structural basis for ubiquitin E1-E2 thioester bond formation. The ...