investigated whether combining a vitamin D analog (paricalcitol) and an angiotensin receptor blocker (losartan) leads to more effective inhibition of the renin–angiotensin system and prevention ...

However, although they share a common mechanism of action, the ARBs differ pharmacologically. [37] Candesartan cilexetil (converted to candesartan) and losartan (converted to EXP-3174) are both ...

The early finding of a decreased stroke rate in losartan-treated patients holds ... use of drugs known to interrupt activity in the renin-angiotensin axis.

An even larger U.S. study showed similar adjusted hazard ratios of 0.70 to 0.75 for ARBs versus other antihypertensive classes, which appeared to be driven by a reduction with losartan.

Angiotensin receptor blockers (ARBs) are a class of oral medications that act primarily through blockade of the angiotensin receptor. The effects of angiotensin include vasoconstriction and ...

The Evaluation of Losartan in the Elderly (ELITE) study demonstrates how an unexpected finding generates research. ELITE started out as a safety and clinical outcome study comparing an angiotensin II ...