For example, at the first Keystone Symposium on Autophagy in Health and Disease, held in 2007 ... revealed an integral role for autophagy in human pathophysiology. Accordingly, there has been ...

Autophagy has been linked to inflammatory bowel disease. Studies of two different mouse strains deficient in the autophagy-related gene product Atg16L1 now show that autophagy is important in ...

Targeting autophagy in this way is a promising approach for promoting the degradation of aggregates that can otherwise form plaques in neurodegenerative diseases ... cells and human cells in ...

By modifying this interaction, it is possible to artificially trigger autophagy, which could then enable the degradation of deposits in neurodegenerative diseases ... cells and human cells in ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

This study was made available online on August 15, 2024 in the journal Autophagy ... "Reduced protein homeostasis is a major characteristic of degenerative diseases such as Alzheimer's and ...

Its disruption is linked to many known diseases in humans, such as Alzheimer's, Parkinson's, and cancer. Though understanding autophagy in ... hyperactivation was a major contributor to cell ...