Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent respiratory diseases.

For instance, research has shown that CD8+ TRM cells exhibit ... plays a crucial role in cell growth, differentiation, and immune responses. Cytotoxic T cells: T cells that can directly kill ...

Philip M and Schietinger A. CD8 T cell differentiation and dysfunction in cancer. Nature Reviews Immunology. 2022 Apr;22(4):209-223. TOX is a critical regulator of tumour-specific T cell ...

CD8 + T cells are vital in defending against infections ... critical signaling pathways influencing T RM cell development and ...

Scientists from A*STAR Genome Institute of Singapore (A*STAR GIS) have uncovered that a key enzyme – P4HA1 prolyl hydroxylase, is strongly induced in CD8+ T cells in solid cancer, the primary immune ...

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

offering not only direct cytotoxicity but also indirect anti-tumour activity through the priming of host CD8+ T cells—a mechanism expected to evade host immune rejection and to enhance the ...