Philip M and Schietinger A. CD8 T cell differentiation and dysfunction in cancer. Nature Reviews Immunology. 2022 Apr;22(4):209-223. TOX is a critical regulator of tumour-specific T cell ...

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

Scientists from A*STAR Genome Institute of Singapore (A*STAR GIS) have uncovered that a key enzyme – P4HA1 prolyl hydroxylase, is strongly induced in CD8+ T cells in solid cancer, the primary immune ...

Within the immune system, CD8 + T cells are the main defensive adaptive ... thus promoting STAT1 phosphorylation and TRM differentiation, which subsequently boosted antitumor immunity in aged ...