Potent in vivo gene editing in skeletal muscle of non-human primates by a novel, ultracompact CRISPR system delivered via a single AAV vector.

Both Cas9 and Cas12a cleave DNA, but they differ in how they cut the molecule.

Experts hailed exciting news for some people with sickle cell disease in England as the health watchdog decided to grant ...

The versatility of Exosome-based delivery systems offers the potential to significantly enhance the therapeutic efficacy of RNA treatments and enable the precise delivery of CRISPR/Cas9 components ...

Get Instant Summarized Text (Gist) CRISPR nucleases, Cas9 and Cas12, have been engineered to evade immune detection, addressing a key challenge in CRISPR-based therapies. By identifying and ...

When the CRISPR Cas9 protein is added to a cell along with a piece of guide RNA, the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a ...

It's clear though that these companies need time. Even with the only approved CAS9 based treatment out there, CRISPR is still years away from achieving its potential. In a recent update to ...

More information: Jihoon Han et al, Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas–based ...

System Biosciences (SBI) develops innovative research tools for MicroRNA research, Exosome research, and Genome Engineering tools, including the CRISPR-Cas9 SmartNuclease system and PrecisionX HR ...