Opioids can modulate endocrine processes (Genazzani ... 1983) which differed in their distribution, ligand binding and function. The endogenous ligands were found in the mid-1970s and were shown ...

The endogenous opioid system, which includes receptors that naturally occurring peptides like endorphins activate, plays a pivotal role in managing pain, reward, and stress responses. This system ...

While men relieve pain by releasing endogenous opioids, the body's natural painkillers, women rely instead on other, non-opioid based pathways. The findings are published in the journal PNAS Nexus.

Animal data has shown significant overlap between the consumption of added sugars and drug-like effects, including bingeing, craving, tolerance, withdrawal, cross-sensitisation, cross-tolerance, cross ...

These mechanisms, rooted in both psychology and neurobiology, involve conditioning, negative expectations and the roles of cholecystokinin, endogenous opioids and dopamine—powerful ...

“What it’s doing is sending gentle neural pulses to the brain, triggering the release of endogenous opioids, or natural pain blockers,” said McGillin. The latest version is 50 percent ...

Specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and play a role in the analgesic effects of this drug.