Small-molecule enzyme-inhibitors often display insufficient affinity and selectivity for their targets causing unwanted side effects when used as drugs. Molecularly imprinted polymers prepared ...

Enzymes are biological catalysts that speed up chemical reactions in living organisms. They are essential for life, as they play a crucial role in various biological processes, such as digestion, ...

A meaningful rank of NSAIDs in terms of inhibition of COX should take into account the complexities inherent in biochemical systems, including the mechanism of catalysis of the endogenous substrate.

11) and our understanding of ACE made a compelling argument for a new attempt at designing small molecular weight inhibitors. We had at our disposal not only an enzyme assay but also a highly ...

(2022) “Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors” J. Vis. Exp. 186, e62949. DOI: 10.3791/62949 Palfey, B. A. and Switzer, ...

or inhibitors of enzymes, can potentially mitigate disease, either by modifying the structure of a natural product or by intervening in a biological process. Enzymes are Nature's dominant catalysts ...

Biosensors based on cholinesterase inhibition have been found to effectively detect biocides in milk, ensuring food safety ...