an induced fit basis for substrate specificity of enzymes was rationalized from simple physical principles of enzyme kinetics. Of particular note is the proposal that ‘entropic guidance’ contributes ...

11) and our understanding of ACE made a compelling argument for a new attempt at designing small molecular weight inhibitors. We had at our disposal not only an enzyme assay but also a highly ...

Enzymes are biological catalysts that speed up chemical reactions in living organisms. They are essential for life, as they play a crucial role in various biological processes, such as digestion, ...

or inhibitors of enzymes, can potentially mitigate disease, either by modifying the structure of a natural product or by intervening in a biological process. Enzymes are Nature's dominant catalysts ...

In the brain, the enzyme ABHD6 degrades a key endocannabinoid molecule known as 2-arachidonoylglycerol (2-AG). With the discovery in 2016 that whole-body inhibition of ABHD6 reduced body weight ...

Biosensors based on cholinesterase inhibition have been found to effectively detect biocides in milk, ensuring food safety ...

A meaningful rank of NSAIDs in terms of inhibition of COX should take into account the complexities inherent in biochemical systems, including the mechanism of catalysis of the endogenous substrate.