In this state, the epitope is shielded to the extent that it can no longer be recognized by the antigen processing transporter (TAP). The linker contains a group that can be split apart by light.
Malaria remains a significant global health challenge, causing over 600,000 deaths annually despite existing prevention and treatment measures. Current vaccines and monoclonal antibodies (mAbs) ...
A collaboration between the Ragon Institute and MIT’s Jameel Clinic has led to the development of MUNIS, a deep learning tool that significantly enhances T cell epitope prediction, accelerating ...
Using our antigen-agnostic workflow ... This new mAb binds to an epitope on PfCSP outside of the central repeat region that is conserved between different strains of P. falciparum.