Cell cycle exit is when cells stop dividing and enter a quiescent state, also named G0. Cells exit the cell cycle in response to nutrient- or growth factor deprivation or in response to signals ...

The 'restriction point' in the mammalian cell cycle is another irreversible transition (G0–G1) that can be understood in the same way 30. In this case, the spring is the activity of the ...

A hallmark of tumor cells is an inability to control their proliferation, which implies that these cells are capable of bypassing cell cycle checkpoints and regulation by tumor suppressor signaling ...