L-838,417 is a partial agonist at α2 ... for the development of subtype-selective GABA A receptor modulators as a potential new class of drugs for chronic pain.

Certain proteins found in the human brain have long been known to be critical to controlling how brain cells communicate with ...

Certain proteins found in the human brain have long been known to be critical to controlling how brain cells communicate with each other.

Medically reviewed by Jonathan Purtell, RDN Increasing gamma-aminobutyric acid (GABA) and balancing glutamate, brain chemicals called neurotransmitters, may help alleviate symptoms of ...

These sleeping pills work on the GABA receptors in the brain, which help control our level of alertness or relaxation. The selective GABA medications target only a certain type of GABA receptor ...

However, the development of antireflux compounds during the past 5 years (mainly GABA B agonists and mGluR5-negative allosteric modulators) has been disappointing as all have been abandoned ...