Data from this study, taken together with three other randomized, double-blind studies comparing candesartan and losartan, demonstrate superior antihypertensive efficacy of candesartan over losartan.

Two classes of antihypertensives target angiotensin ... (lisinopril and hydrochlorothiazide); ARBs and diuretics (losartan or valsartan and hydrochlorothiazide); and diuretics and diuretics ...

CLAIM Study Investigators: Amin Abdelghany, MD, Panama City, FL; Allen B. Adolphe, MD, Albuquerque, NM; J. Richard Allison, MD, Columbia, SC; Norse Bear, MD, Lakewood ...

The reduction in proteinuria was greater when losartan was combined with a low ... and a diuretic are equally effective at enhancing the antihypertensive and antiproteinuric effects of RAAS ...

An even larger U.S. study showed similar adjusted hazard ratios of 0.70 to 0.75 for ARBs versus other antihypertensive classes, which appeared to be driven by a reduction with losartan.