Peptide-centric approaches—sometimes referred to as shotgun strategies or bottom-up proteomics—are now widely adopted as a means of identifying proteins present in biological mixtures.

Named after shotgun DNA sequencing, in which long DNA sequences are computationally reconstructed from many short sequencing reads, shotgun proteomics identifies proteins from tandem mass spectra ...

Mass spectrometry (MS) plays an important role, with peptide mapping being the gold standard to assess post-translational modifications (PTM). However, traditionally used collision-induced ...

However, the peptide must reverse its twist to relieve the torsional strain and by doing so disrupts the tau fibril, enabling its fragmentation. We are currently characterizing the fragments produced ...