Cytotoxic or CD8 + T-cells, known for their ability to kill infected and cancer cells, require activation and differentiation within specialized niches of the tumor microenvironment to effectively ...

More information: Hongxing Shen et al, HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells, Nature Communications (2024). DOI: 10.1038 ...

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent ...

Unrelated human MSCs did not elicit T-cell activation in vitro and suppressed T-cell activation by Tuberculin and unrelated allogeneic lymphocytes in a dose-dependent manner. Cell-free MSC culture ...

An international team of UK and US scientists has discovered that the activity of macrophages—a type of white blood cell that ...

Oncolytic adenoviruses were designed to reach potent intratumoral T-cell activation via expression of bifunctional-T-cell ...

T cells are designed to recognise the molecular signatures of particular proteins, such as those from bacteria, in order to activate an immune response. Macrophages eat other cells and are able to ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of ...

HIF1α identified as key regulator that induces cancer-killing ability of hypoxic T cells, playing a role in ICB resistance.