Cytotoxic or CD8 + T-cells, known for their ability to kill infected and cancer cells, require activation and differentiation within specialized niches of the tumor microenvironment to effectively ...

Unrelated human MSCs did not elicit T-cell activation in vitro and suppressed T-cell activation by Tuberculin and unrelated allogeneic lymphocytes in a dose-dependent manner. Cell-free MSC culture ...

New findings reveal how cancer manipulates immune pathways and highlight therapeutic strategies to unleash T-cells against even the most resistant tumors. Study: Cancer cells impair monocyte ...

More information: Hongxing Shen et al, HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells, Nature Communications (2024). DOI: 10.1038 ...

The direct-to-cell Starlink system in Southern California will deliver wireless emergency alerts and power SMS texting to 911 ...

Additionally, previous research has monitored amounts of protein indicators such as PD-L1 and at the genes involved in T cells to assess whether immunotherapy is effective. However, this latest study ...

About the Phase 1 First-in-human Study of LAVA-1266 (ACTRN12624001214527) ...