通过线粒体转移，癌细胞不仅实现了对T细胞功能的精确抑制，还为其免疫逃逸增加了一道屏障。该研究进一步指出，这种机制与免疫治疗效果不佳密切相关，尤其是在携带大量mtDNA突变的患者中，免疫检查点抑制剂的疗效显著降低。

Research led by the Chiba Cancer Center Research Institute in Japan has discovered a surprising way cancer evades the immune ...

The malfunctioning mitochondria seem to poison the immune cells, explains Yosuke Togashi, a pulmonary physician and ...

A new study from Oregon Health & Science University has uncovered how small molecules within bacteria interact with proteins, ...

Their role in transporting immune checkpoint molecules such as PD-L1 further underscores their impact on tumor immune evasion. HCC-Derived Exosomes in Immune Modulation ...

Discovery-driven science leading to real-world applications': Study opens new pathways for cancer research, treatments Andrew ...

KSHV can be found in connection with many types of cancer, especially those with ... “This suggests the virus may be using LANA as an immune evasion tactic, preventing the immune system from ...

Russell W. Jenkins, MD, PhD, a physician investigator in the Krantz Family Center for Cancer Research at the Mass General Cancer Center and an ...

CY-101 is under clinical development by Cytovation and currently in Phase II for Lymphoma. According to GlobalData, Phase II drugs for Lymphoma have a 30% phase transition success rate (PTSR) ...

Metastatic latency and immune evasion through self-imposed growth arrest in metastasis initiating cells (from Malladi et al Cell 2016). Regenerative lineages and immune-mediated pruning of cancer ...