As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent ...

Dark zone lymphoma includes aggressive B-cell lymphomas with shared molecular features. While some respond to escalated ...

Objectives To examine the mechanism by which cellular metabolic reprogramming regulates human B cell differentiation in vitro, and its involvement in pathological processes of SLE. Conclusions CpG and ...

Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. Previously, we showed that cell size control involves both cell ...

In blood cancers such as chronic lymphocytic leukemia, B cells of the immune system multiply uncontrollably. One form of ...

Upon engagement, PB-CAR-NK cells become activated and secrete various soluble factors (e.g., perforin [PFN], granzyme B [GzmB], cytokines, and chemokines), which are critical for their effector ...

TOPLINE: Sjögren disease (SjD) presents three distinct phenotypes ― B-cell active with low symptom burden, high systemic ...

Adjuvants primarily enhance antigen-induced adaptive immunity by promoting the activation of antigen-presenting cells (APCs).This study is to develop an adjuvant targeted ... Ovalbumin (OVA) (Solarbio ...

Thanks to an innovative method of super-resolution microscopy, researchers observed with molecular resolution in 3D how therapeutic antibodies attack and alter B cells, thereby inducing their ...