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清华大学重磅突破:这种免疫细胞是鼻炎易复发的关键因素
为了验证颗粒酶K在疾病进展中的作用,研究团队构建了小鼠哮喘模型。结果表明,随着气道炎症的复发次数增加,颗粒酶K的表达水平也随之上升。当通过基因敲除或药理学方法抑制颗粒酶K活性时,小鼠的呼吸道炎症明显减轻,肺功能得到改善。使用颗粒酶K特异性抑制剂PPA ...
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