Levodopa is the most efficacious agent for the treatment of motor features of Parkinson's disease but its chronic use is associated with the development of motor complications. Mounting evidence ...

Improvements in levodopa pharmacokinetics with the addition ... safety and tolerability of entacapone with the most common side effects being increased dyskinesias, diarrhea and urine discoloration.

Parkinson’s disease is a progressive neurodegenerative disorder that affects millions of people worldwide. In the United ...

These side effects include: COMT inhibitors are ... They are usually prescribed in combination with carbidopa and levodopa.