Peak fluconazole concentrations of 16–32 µg/ml were reached in all patients. Mean concentrations above 16 µg/ml were maintained for 17.0 ± 8.0 h at an ultrafiltration rate of 1,000 ml/h, ...

This open-label Phase 1 study evaluated the pharmacokinetics (PK) and safety of ETR in the presence of fluconazole (moderate CYP2C9 and CYP3A4 inhibitor; strong CYP2C19 inhibitor), gemfibrozil (strong ...

Causes other than fluconazole prophylaxis that might have ... The Unit's policy on empiric antibiotic use, particularly cephalosporin use, did not vary during the study period.