Ubiquitin is an intracellular signalling molecule that is conjugated to various ... the UBD and conformational changes following binding. Structures of ubiquitin–UBD complexes have revealed ...

Figure 1: Domain structure of ubiquitin-specific proteases. DUB activities fall into three major functional categories (Fig. 3). First, ubiquitin can be transcribed from several genes as a linear ...

Molecular Cancer Therapeutics publishes articles on the discovery and preclinical development of novel therapeutic agents for oncology, preclinical studies of approved therapeutics, mechanisms of drug ...