Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell ...

Scientists at Children’s Medical Research Institute (CMRI) have solved a remarkable puzzle in cancer research: why cells die in different ways following radiotherapy.

The research demonstrated that inhibiting the homologous recombination pathway alters the manner of cancer cell death, prompting a robust immune response. Additionally, it was found that cancer cells ...

"The surprising result of our research is that DNA repair, which normally protects ... therapy was repaired by a method called homologous recombination, cancer cells died during the process ...

The team showed that blocking homologous recombination changed the way the cancer cells died – i.e., they ... “We found that the manner in which tumour cells die after radiotherapy depends on the ...

Developed in-house by Serra’s laboratory, a test based on the detection of the RAD51 protein as a functional biomarker of homologous recombination ... DNA damage repair (DDR) pathway.

When DNA damage from radiation therapy was repaired using homologous recombination, cancer cells died during cell division but didn ... “We found that how tumor cells die after radiotherapy depends on ...

This month's cover highlights the article The Dystrophin-Dystroglycan complex ensures cytokinesis efficiency in Drosophila epithelia by Eurico Morais-de-Sá, Margarida Gonçalves and colleagues. The ...

Aging is the process of gradual functional decline that an organism experiences over time. Because aging is the main risk factor for neurodegenerative diseases (NDs) (Hou et al., 2019), an ...