In the current study we analysed expression of VEGF and its receptors in human hepatocellular carcinoma (HCC) and investigated the molecular mechanisms of VEGF regulation by hypoxia. METHODS VEGF, ...

Brain injury resulting from hypoxia (oxygen deprivation) or ischemia (restricted blood flow) represents a major challenge in medical research and clinical ...

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Netherlands Activation of the phosphatidylinositol-3-kinase (PI3-K)/protein kinase B (AKT) pathway is associated with ...

Although maternal iron imbalance and placental hypoxia are independent contributors to the pathogenesis of preeclampsia, a hypertensive disorder of pregnancy, the mechanisms by which their interaction ...

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, and MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR ...

Dihydromyricetin (Dih), a naturally occurring flavonoid, has been identified to exert a protective effect against ischemia/reperfusion injury. However, the detailed mechanisms remain unclear. Here we ...

Kenneth Eugene Smith, an inmate in the US State of Alabama, Thursday became the first person ever to be put to death through the controversial nitrogen hypoxia mechanism. Ecuador's Foreign ...

The pathophysiology of residual sleepiness in treated obstructive sleep apnoea (OSA) remains poorly understood. Animal models ...