This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides ...

In inflammatory responses, Natural products effectively inhibit the expression of TLR4, thereby interrupting its recognition of pathogen-released LPS from bacteria, viruses, and other pathogens, thus ...

TLR4 recognizes lipopolysaccharides (LPS) from bacterial cell walls, and its hyperactivation can lead to various inflammatory diseases. Recent reviews have discussed the development of TLR4 ...

ENO1 also exhibits this pro-inflammatory effect on cells from RA patients. Then, we demonstrated that ENO1, which exclusively bound monocytes, exhibited a LPS-like action mediated by TLR4. More ...

We report here for the first time that high-fat feeding augments plasma LPS at a concentration sufficient to increase body weight, fasted glycemia, and inflammation. LPS infusion in normal diet ...

Cell ...

【导读】癌相关成纤维细胞（CAFs）在肝细胞癌（HCC）的发生和发展中发挥着重要作用，并且是免疫抑制微环境的关键组成部分。然而，CAFs 的起源尚未完全阐明。1月18日，上海中医药大学/国家肝癌科学中心/海军军医大学研究人员共同在期刊《Cell Death&Disease》上发表了题为“ERG mediates the differentiation of hepatic ...

The move to tap Skretta, the associate superintendent of civic engagement and the district's chief lobbyist, essentially buys the board more time to conduct a search to find LPS' next permanent ...

The aim of the present study was to estimate the change in TLR4 mRNA expression in the liver, kidney's pleen, heart, and small intestine of broiler chickens under AHS. A total of 240 healthy Arbor ...

Apple is developing a new version of the iPhone SE, which is expected to feature some major changes. In addition to a new, larger size, Apple will also do away with Touch ID, and add support for ...