Sirtuins, identified as (NAD +)- dependent class III histone deacetylases, engage in a spectrum of biological functions, encompassing DNA damage repair, oxidative stress, immune modulation, ...
Aging results increased mitochondrial dysfunction and increased oxidative stress. There is a dysregulated energy metabolism with altered calcium homeostasis.
Researchers in India have developed a new nanoformulation that may improve the safety and efficacy of Parkinson's disease treatment, IANS, a partner ...
Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen species (ROS) management and Ca 2+ signaling. In particular ...
1 Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China 2 Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Key ...
Targeting calcium channels and exchangers has emerged as a promising strategy to restore calcium homeostasis and improve cardiac function[5]. Mitochondrial Calcium Uniporter (MCU): A protein that ...