Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

Figure 1: Interference of MHC multimer staining with T-cell function in vitro. Figure 2: Interference of MHC multimer staining with T-cell function in vivo. Several factors must be considered in ...

We showed that MATEs are capable of binding to murine and human T cells leading to their effective activation in vitro and that their expression can confer T-cell mediated cytotoxicity to neighboring ...

VPA treatment enhanced the susceptibility of glioblastoma cells to NKG2D CAR-T mediated cytotoxicity in both 2D monolayer and 3D tumor spheroid models in vitro. Moreover, VPA-treated glioblastoma ...

Jan. 31, 2025 — Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders -- T cells -- lose their ability to ...

Functional differences were studied using in vitro cytotoxicity, degranulation and cytokine expression assays. CAR T cell exhaustion and differentiation were studied using ... Densitometric analysis ...

T-cell lymphoma is a type of lymphatic cancer that starts in the T lymphocytes (T cells), a type of white blood cell. T lymphocytes (T cells) and B lymphocytes (B cells) are two types of white blood ...

The SIRPγ-CD28 coreceptor was included to improve the persistence, proliferation, and cytotoxicity of the CAR-T cells. The study involved in vitro assays and in vivo mouse models to evaluate the ...

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

Department of Biology and Environmental Science, Linnaeus University, Stuvaregatan 4, 392 31 Kalmar, Sweden ...

Meanwhile, Creative Biolabs has developed a series of CAR-T cell in vitro assays in response to the urgent need for rapid assessment of CAR-T cell functions. These enable the comprehensive evaluation ...