This physical structure is characterized by a continuous remodeling, which allows cells to accomplish complex motility steps such as directed migration ... different signaling areas. The integrin ...

However, when sensing the presence of chemokine signals at the vicinity of organs such as lymph nodes, T cells rapidly become elongated and polarized to cross the blood vessels and enter the tissues.

Both migration and phagocytosis ... In addition, HEM1-deficient thymocytes and T cells displayed defective actin polymerization and capping, and decreased integrin-mediated adhesion to fibronectin ...

A substantial and persuasive body of data now exists that supports the view that integrin alpha V beta 3 plays a critical part in activated macrophage dependent inflammation, osteoclast development, ...

Small-cell lung cancer (SCLC), accounts ... while inhibition of ECM degradation inhibits cellular migration and metastasis, it may also promote tumour growth and drug resistance. Inhibition of ...