Objective An international meeting was organised to develop consensus on (1) the landmarks to define the gastro-oesophageal junction (GOJ), (2) the occurrence and pathophysiological significance of ...

Background Chicoric acid (CA), a hydroxycinnamic acid, has been reported to possess anti-inflammation activities. However, the specific mechanisms by which CA influences dextran sulfate sodium ...

Background and objective Gastric cancer (GC) remains a prevalent and preventable disease, yet accurate early diagnostic ...

Dr P Sharma, Assistant Professor of Medicine, University of Kansas, Gastroenterology Section (111), VA Medical Center, 4801 E Linwood Blvd, Kansas City, MO 64128, USA. BACKGROUND Biopsy specimens ...

Objective Patients with increased PD-L1 + host cells in tumours are more potent to benefit from antiprogrammed death-1/programmed death ligand-1 (PD-L1) treatment, but the underlying mechanism is ...

Correspondence to Dr Noel F C C de Miranda, Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; N.F.de_Miranda{at}lumc.nl Objective Biological insights into the stepwise ...

1 Liver Unit, Department of Medicine A, Imperial College School of Medicine, St Mary’s Hospital Campus, South Wharf Street, London W2 1PG, UK 2 Department of Hepatobiliary Surgery, Royal Free Hospital ...

Objective In acute pancreatitis (AP), bacterial translocation and subsequent infection of pancreatic necrosis are the main risk factors for severe disease and late death. Understanding how ...

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...

Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. Understanding the pathological and molecular hallmarks from its first description to ...

Correspondence to Professor Lee-Yan Sheen, Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan; lysheen{at}ntu.edu.tw and Professor Ming-Shiang Wu, Department of ...

Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Conclusion Our ...