This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

Jan. 28, 2025 — A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse -- a mouse with two male parents -- that lived until adulthood.

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Researchers discover how Zika virus and related viruses replicate in human cells, illuminating potential new vaccines.

human embryonic kidney 293T (HEK293T) cells, and primary myocytes. This activation was determined by estimating the phosphorylation levels of AMPKα (pAMPKα) and substrate acetyl coenzyme A ...

Nanodiamonds were purchased from Sigma-Aldrich (USA). miR-7 was obtained from GenePharma (Shanghai, China). SH-SY5Y, MN9D and HEK293T cell lines were purchased from Cell Bank of Chinese Academy of ...

Jan. 28, 2025 — A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse -- a mouse with two male parents -- that lived until adulthood.

The luminescence intensity of the Jurkat cells was measured using a plate reader, serving as an indicator of their activation level in response to CAR activation. CAR lentivirus was produced by ...

Epidermal growth factor receptor (EGFR) is a major driver of cancer dissemination and target for anti-cancer therapies but ...

Objective Patients with increased PD-L1 + host cells in tumours are more potent to benefit from antiprogrammed death-1/programmed death ligand-1 (PD-L1) treatment, but the underlying mechanism is ...