We have also determined the cryo-EM structure of the complex formed by anti-CRISPR protein AcrVIA1 and crRNA-bound type VI Cas13a. Our studies establish that AcrVIA1 interacts with the guide exposed ...

CRISPR gene editing and next-generation sequencing (NGS) have transformed clinical and life sciences research. CRISPR permits the selective targeting and editing of specific nucleotide sequences ...