Now, Scripps Research scientists have uncovered new structures of transthyretin. Their findings, published in Nature Structural & Molecular Biology on January 22, 2025, show how the three-dimension ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Although scientists can learn a lot from cell culture and animal models, they cannot truly substitute for all parts of the ...

Certain proteins found in the human brain have long been known to be critical to controlling how brain cells communicate with each other.

Certain proteins found in the human brain have long been known to be critical to controlling how brain cells communicate with ...

This article is part of the Research Topic Dysfunctions in GABAergic Signaling in Neurological Disorders View all articles The probands are sisters, age 27 and 25, who both presented with epilepsy ...

However, how it is able to recognize and transport a wide range of diverse substrates remains poorly understood. Here we present cryo-EM structures of lipid-embedded human ABCB1 in conformationally ...

State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, ...