Small-molecule enzyme-inhibitors often display insufficient affinity and selectivity for their targets causing unwanted side effects when used as drugs. Molecularly imprinted polymers prepared ...

The Post group has worked to understand the basis of the catalytic power of enzymes using information from crystallography, kinetics, and a description of conformational distributions from molecular ...

For example, conformational changes in enzymes may be crucial for optimal ... directed towards understanding protein folding and catalysis. The foundation of the text is grounded on solid ...

or inhibitors of enzymes, can potentially mitigate disease, either by modifying the structure of a natural product or by intervening in a biological process. Enzymes are Nature's dominant catalysts ...

In the brain, the enzyme ABHD6 degrades a key endocannabinoid molecule known as 2-arachidonoylglycerol (2-AG). With the discovery in 2016 that whole-body inhibition of ABHD6 reduced body weight ...

Enzymes are biological catalysts that speed up chemical reactions in living organisms. They are essential for life, as they play a crucial role in various biological processes, such as digestion, ...

Biosensors based on cholinesterase inhibition have been found to effectively detect biocides in milk, ensuring food safety ...

(2022) “Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors” J. Vis. Exp. 186, e62949. DOI: 10.3791/62949 Palfey, B. A. and Switzer, ...