Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

Cells were collected and lysed with a lysis buffer (50 mM Tris (pH 7.4), 150 mM NaCl, 1% NP-40, 10% glycerol and 1 mM EDTA (pH 8.0)) supplemented with 1 mM PMSF and 1 mM NaF for 20 min on ice. The ...

Accumulating evidence reveals that adipose tissue is an immunologically active organ that exerts multiple impacts on the regulation of systemic energy metabolism. Adipose tissue immunity is modulated ...