Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Homologous Recombination as a Major DNA Repair Pathway in Mammalian Cells Postdoctoral fellow Christine Richardson has demonstrated that mouse chromosomes 17 (red) and 14 (green) can be induced to ...

Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell ...

"The surprising result of our research is that DNA repair, which normally protects ... therapy was repaired by a method called homologous recombination, cancer cells died during the process ...

Scientists at Children’s Medical Research Institute (CMRI) have solved a remarkable puzzle in cancer research: why cells die in different ways following radiotherapy.

The team showed that blocking homologous recombination changed the way the cancer cells died – i.e., they ... “We found that the manner in which tumour cells die after radiotherapy depends on the ...

Developed in-house by Serra’s laboratory, a test based on the detection of the RAD51 protein as a functional biomarker of homologous recombination ... DNA damage repair (DDR) pathway.