研究选择LPS（TLR4配体）深入探讨分子机制，发现LPS处理后小胶质细胞系BV-2中自噬受抑制，而在骨髓来源的巨噬细胞（BMDM）及小鼠巨噬细胞系Raw264.7 ...

Toll-like receptor (TLR) 4 recognises lipopolysaccharide (LPS), resulting in activation of an inflammatory cascade via the accessory protein MyD88. Aims: To investigate role of TLR4 in inflammatory ...

Spatially restricted expression of Toll-like receptor 4 (Tlr4) in stomach and colon, but not in small intestine, is matched by nuclear factor kappa B (NF-κB) responses to lipopolysaccharide (LPS) ...

We report here for the first time that high-fat feeding augments plasma LPS at a concentration sufficient to increase body weight, fasted glycemia, and inflammation. LPS infusion in normal diet ...

That finding, we believe, should raise concerns regarding the proposal by Blander and Medzhitov that LPS modulates dendritic cell phagosomes directly through TLR4 stimulation 5, a proposal ...

ENO1 also exhibits this pro-inflammatory effect on cells from RA patients. Then, we demonstrated that ENO1, which exclusively bound monocytes, exhibited a LPS-like action mediated by TLR4. More ...

Despite their advantages, the high lipopolysaccharide (LPS) endotoxin content in the OMVs raises significant safety and regulatory challenges. In this work, we produce LPS-attenuated and LPS-free OMVs ...

LPS+ESO-treated mice were rechallenged with LPS of which 80% survived compared to 0% in the control mice. ESO-treated mice had significantly lower serum TNF-α, IL-1ß, and MΦs. The TLR agonism was also ...

Cartier previously ran for the LPS school board in 2015 as a law student, losing to Annie Mumgaard. As a board member, Cartier said his main focus would be on the district's use of property taxes ...