The SV is unique to fish and coronet cells are CSF-contacting neurons. Here, we discuss the universality and diversity of signal transduction pathways that regulate vertebrate seasonal reproduction.

A new study shows how an anticancer drug triggers an “outside in” signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals ...

尽管如此，本研究为 65 岁以上老年人接种三种基于蛋白的含 XBB 疫苗后的中和抗体反应提供了重要证据，为优化老年人群疫苗接种策略、增强对新兴 SARS-CoV-2 变体的中和免疫力提供了关键信息。未来需进一步研究不同给药途径疫苗诱导的免疫特征、年龄对加强免疫后免疫力持久性的影响以及疫苗对新变体的效力等问题，以更好地应对新冠疫情，保障老年人群健康。

Septerna has a market cap of $750mn and $130mn in cash and ST investments. Discover SEPN's groundbreaking drug discovery ...

Schematic depicting the involvement of regional sympathetic nerves in the mediation of pain in early-stage TMJ-OA. GA, UNITED STATES, Febru ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

Researchers are enhancing the best features of AAV capsids and overcoming their limitations to accelerate gene-based therapies.

Recent studies showed that a peptide, the protein transduction domain (PTD) from HIV Tat, could improve the distribution of cytoplasmic reporter proteins when administered systemically as fusion ...

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The Signal is produced by senior students at the University of King’s College School of Journalism, Writing & Publishing.

Despite a fierce second-half effort from Golden Valley, the Hart boys’ soccer team kept its perfect Foothill League campaign alive ...

在近期发表于《自然》杂志的一项研究中，诺德曼等人确定 Janus 激酶抑制剂（JAKi）可作为治疗危及生命的中毒性表皮坏死松解症（TEN）的新选择。他们通过对人体皮肤样本进行空间蛋白质组学分析，并在 TEN 患者体内给予 JAKi，证明了这一疗法能使患者快速重新上皮化并康复。由于 TEN 的死亡率高达 30 - 50%，该研究为靶向治疗开辟了一条新途径。