Cytotoxic or CD8 + T-cells, known for their ability to kill infected and cancer cells, require activation and differentiation within specialized niches of the tumor microenvironment to effectively ...

Unrelated human MSCs did not elicit T-cell activation in vitro and suppressed T-cell activation by Tuberculin and unrelated allogeneic lymphocytes in a dose-dependent manner. Cell-free MSC culture ...

New findings reveal how cancer manipulates immune pathways and highlight therapeutic strategies to unleash T-cells against even the most resistant tumors. Study: Cancer cells impair monocyte ...

Two main sub-types of immune cells are T cells and macrophages. T cells are designed to recognise the molecular signatures of particular proteins, such as those from bacteria, in order to activate an ...

More information: Hongxing Shen et al, HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells, Nature Communications (2024). DOI: 10.1038 ...

Additionally, previous research has monitored amounts of protein indicators such as PD-L1 and at the genes involved in T cells to assess whether immunotherapy is effective. However, this latest study ...

The direct-to-cell Starlink system in Southern California will deliver wireless emergency alerts and power SMS texting to 911 ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

it is an important transcription factor that regulates CD8+ T cell activation and exhaustion. The current study explored the roles of ACSS2 and ACLY in TEX cell formation during chronic LCMV ...