Elongator, an established tRNA-modifying complex, can also stabilize microtubules during asymmetric cell division. This study shows that Elongator subcomplexes achieve this by binding to microtubule ...

Pancreatic cancer is a challenge due to its poor prognosis and high mortality rate, highlighting the need for new therapeutic approaches. Previous findings have shown that AUS-001 inhibits β-tubulin ...

The predicted E2 binding residues of the HsIFT172 U-box domain are depicted in the model ... A mouse monoclonal antibody against acetylated tubulin (Sigma-Aldrich, Clone 6-11B-1, diluted 1:500) was ...

Ubiquitin-binding domains (UBDs) are modular elements that bind non-covalently to the protein modifier ubiquitin. Specific ubiquitin–UBD interactions are crucial for the regulation of multiple ...

After hours: January 31 at 4:33:08 PM EST Loading Chart for MNOV ...

The PIF/Harbinger-derived ADF-IL protein recruits KAT2B to drive its nuclear translocation and local chromatin acetylation, ...

Androgen deprivation is the mainstay of advanced prostate cancer treatment. Despite initial responses, almost all patients progress to castration-resistant prostate cancer (CRPC). The ...

Microtubules are cylindrical polymers composed of alpha and beta tubulin. They are a major component of the cytoskeleton and mediate crucial cellular functions including formation of the mitotic ...

Telotristat ethyl to promote weight stability in patients with advanced pancreatic cancer. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers Symposium. This abstract does ...

School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People’s Republic of China ...

Aim: Kidney impairment is observed in patients with COVID-19. The effect of anti-COVID-19 agent remdesivir on kidneys is currently unknown. We aimed to determine the effect of remdesivir on renal ...

Introduction: Chronic inflammation caused by Escherichia coli infections has a significant negative impact on the reproductive system and impairs fertility. The corpus luteum (CL) plays a central role ...