Notch1 is expressed uniformly throughout the mouse endocardium during the initial stages of heart valve formation, yet it remains unclear how Notch signaling is activated specifically in the AVC ...

2024). Besides, The Munc18-1 interacting protein 3- (Mint3)-activated hypoxia-indued factor 1α (HIF-1α) signaling promotes chemoresistance in triple-negative breast cancer (TNBC) by increasing the ...

In terms of regulatory mechanisms, circ_0022382 activated PI3K/AKT/mTOR signaling pathway and SLC7A11 by sponging let-7a-5p, while knockdown of circ_0022382 contributed to the occurrence of ...

Currently, four VEGF receptor inhibitors (sorafenib, sunitinib, pazopanib and axitinib), one anti-VEGF monoclonal antibody (bevacizumab) and two inhibitors of the mTOR pathway (temsirolimus and ...

Together, our findings identify an essential role of AurA in regulating trained immunity via a methylation-dependent manner by maintaining endogenous SAM level through mTOR-FOXO3-GNMT axis. In this ...

相关研究结果于2025年1月1日在线发表在Nature期刊上，论文标题为“Dysregulation of mTOR signalling is a converging mechanism in lissencephaly”。 论文共同通讯作者 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Thermogenic fat, including brown and beige fat ...

The Systems Virology lab at Laboratory Medicine focuses on using systems biology and experimental approaches to understand the biology of host-pathogen interactions targeted towards the RNA viruses.

Includes reviews of 1A Auto Sales from DealerRater. Want to share your experience with this dealership? Beautiful Made everything very clear No problem understandy anything Viewing the cars we're ...