Mrs K Cauch-Dudek, Toronto Hospital, Western Division, 399 Bathurst St, West Wing 4–833, Toronto, Ontario M5T 2S8, Canada. Background—Fatigue is a frequent and debilitating symptom in patients with ...

Objective To determine whether proton pump inhibitors (PPIs) are associated with an increased risk of colorectal cancer, compared with histamine-2 receptor antagonists (H2RAs). Design The United ...

Background: Three large randomised trials have shown that screening for colorectal cancer using faecal occult blood (FOB) tests can reduce the mortality from this disease. Two national pilot studies ...

Intestinal permeability was estimated in healthy subjects after ingestion of aspirin (1.2+1.2 g), ibuprofen (400+400 mg) and indomethacin (75+50 mg) at midnight and an hour before starting a ...

Correspondence to: Dr M Prince, Centre for Liver Research, 4th Floor William Leech Building, Newcastle University Medical School, Framlington Place, Newcastle NE2 4HH, UK; Martin.prince{at}ncl.ac.uk ...

Background—The aetiology and pathology of both idiopathic megarectum and idiopathic megacolon are unknown. In particular, it is unknown whether there are abnormalities involving enteric nerves or ...

Background and aims: Acid secretion plays an important role in the ecology of Helicobacter species and acid secretory status heralds patterns of gastritis. The presence of inflammatory cells and their ...

2 Microbiology and Tumour Biology Centre, Karolinska Institute, Stockholm, Sweden 3 Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden 4 Microbiology and Tumour ...

Introduction Nutrition therapy in treatment of Chron’s Disease (CD) is not adequately highlighted in adult guidelines despite strong evidence supporting its therapeutic efficacy and thus, this option ...

Introduction Etrasimod (ETR), a once-daily (QD), oral, selective sphingosine 1-phosphate receptor modulator in clinical development for immune-mediated inflammatory disorders, is a substrate of ...

In the past few years, optical magnification endoscopy and chromoscopy have gained renewed interest in the West as a means for the early detection of minute lesions in patients with Barrett’s ...

Background While Alistipes putredinis (AP) abundance in the faeces of patients with inflammatory bowel disease (IBD) decreases, its role in IBD is not well understood. We, therefore, investigated the ...