Stress fibers are primarily composed of actin and myosin. Actin is a ~43kDa globular protein, and can polymerize to form long filamentous structures. These filaments are made of two strands of actin monomers (or protofilaments) wrapping around each other, to create a single actin filament.

2012年4月15日 · Stress fibers are contractile actomyosin bundles found in many cultured non-muscle cells, where they have a central role in cell adhesion and morphogenesis. Focal-adhesion-anchored stress fibers also have an important role in mechanotransduction.

Stress fibers are contractile bundles of actin filaments, crosslinked by α-actinin, that anchor the cell and exert tension against the substratum. They are attached to the plasma membrane at focal adhesions via interactions with integrin.

2012年4月15日 · Stress fibers are contractile actomyosin bundles found in many cultured non-muscle cells, where they have a central role in cell adhesion and morphogenesis. Focal-adhesion-anchored stress fibers also have an important role in mechanotransduction.

2007年10月15日 · Recent studies have defined regulatory mechanisms that control stress fibre formation, placing the ROCK protein kinase at the centre of a complex signalling network controlling actomyosin contractility and stress fibre assembly.

Stress fibers are actomyosin-based bundles whose structural and contractile properties underlie numerous cellular processes including adhesion, motility and mechanosensing. Recent advances in high-resolution live-cell imaging and single-cell force ...

2023年11月30日 · These are dorsal stress fibers, ventral stress fibers, transverse arcs, and the recently identified perinuclear actin cap, which is an important mediator in nuclear mechanotransduction. Each type of stress fiber is defined by their location in the cell, their morphology and their function at focal adhesions (reviewed in [3]).

Contractile actomyosin bundles, stress fibers, govern key cellular processes including migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental morphogenesis. The most prominent actomyosin bundles, ventral stress fibers, are generated through coalescence of pre-existing stress fiber precursors.

Microinjection of the catalytic domain of Rho-kinase into serum-starved Swiss 3T3 cells induced the formation of stress fibers and focal adhesions, whereas microinjection of the inactive catalytic domain, the Rho-binding domain, or the pleckstrin-homology domain inhibited the LPA-induced formation of stress fibers and focal adhesions.

2010年4月4日 · As these large bundles of actin, called stress fibers, appear preferentially on stiff surfaces, our mechanical model provides a mechanism for stress fiber formation and stiffness sensing in cells adhered to a compliant surface. Keywords: biological friction, cell biomechanics, cytoskeleton, focal adhesions, mechanosensitivity.