2020年11月18日 · In this review, we summarise data from published literature on the effect of chromosomal instability and genetic mutations on cancer cell migration and invasion. Genetic …

2003年5月1日 · Learning more about the cellular and molecular basis of these different migration/invasion programmes will help us to understand how cancer cells disseminate and …

Metastasis is a dynamic process in which cancer cells navigate the tumor microenvironment, largely guided by external chemical and mechanical cues. Our current understanding of …

2024年9月30日 · Cell migration is essential for diverse physiological and pathological processes and is dysregulated in cancer to favour cell invasion and metastasis. Here, we discuss recent …

Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations determine cancer cell fate by affecting cell proliferation, apoptosis and immune response, and increasing …

2021年1月1日 · Cancer cells can disseminate and migrate via several alternative mechanisms including amoeboid cell migration, mesenchymal cell migration, and collective cell migration. …

2023年8月16日 · We propose that fibroblast tracks represent a topography-based intercellular communication system capable of steering cancer cell migration. Cell migration is fundamental …

Invasion of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. This requires chemotactic migration of cancer cells, steered by protrusive activity …

2024年3月13日 · We find that the histone methyltransferase Mixed-Lineage Leukemia 1 (MLL1) controls 3D cell migration via cytokines, IL-6, IL-8, and TGF-β1, secreted by the cancer cells …

Metastasis is a multistep process that includes migration and invasion of cancer cells, hallmarks of malignancy. These processes require the involvement of a wide array of cellular …