Scientists Regenerate Hair Cells that Enable Hearing
2023年4月19日 · The researchers then combined the chemical compounds and siRNA molecules into a drug-like cocktail. They delivered it to the inner ear of a normal adult mouse with …
Mechanisms of hair cell damage and repair - PMC - PubMed …
Hair cells acquire damage from a variety of environmental and genetic factors. To fully maintain auditory function, damaged hair cells must be repaired. Broken tip links are repaired in both …
Approaches to Treat Sensorineural Hearing Loss by Hair-Cell ...
Hair-cell damage is repaired in the ears of regenerative species through two processes: transdifferentiation and asymmetric division. Transdifferentiation occurs when supporting cells …
Murine cochlear damage models in the context of hair cell …
2024年6月1日 · A researcher might want to study mild damage, such as a temporary hearing threshold shift (TTS) without hair cell death, or the goal may be to induce massive cochlear …
In situ regeneration of inner hair cells in the damaged cochlea by ...
2023年12月15日 · Cochlear inner hair cells (IHCs) are primary sound receptors, and are therefore a target for developing treatments for hearing impairment. IHC regeneration in vivo has been …
In situ regeneration of inner hair cells in the damaged cochlea by ...
2023年12月11日 · Our findings suggest that the defective MET is a critical barrier that prevents the restoration of hearing capacity and should thus facilitate future IHC regeneration studies. …
BRCA1 Promotes Repair of DNA Damage in Cochlear Hair Cells …
2024年10月16日 · In this study, we showed that cisplatin induced DNA damage in outer hair cells (OHCs) and promoted OHC loss, leading to hearing loss in mice of either sex. Cisplatin …
Optimized inner ear organoids for efficient hair cell generation …
2025年1月23日 · Hair cells in the mammalian cochlea are highly vulnerable to damage from drug toxicity, noise exposure, aging, and genetic mutations, with no capacity for regeneration. …
Mechanisms of Hair Cell Damage and Repair - ScienceDirect
2019年6月1日 · Hair cells acquire damage from a variety of environmental and genetic factors. To fully maintain auditory function, damaged hair cells must be repaired. Broken tip links are …
Reprogramming by drug-like molecules leads to regeneration of cochlear …
Strategies to overcome irreversible cochlear hair cell (HC) damage and loss in mammals are of vital importance to hearing recovery in patients with permanent hearing loss. In mature …