2024年7月9日 · Fluconazole works by targeting a key enzyme (lanosterol 14-alpha-demethylase) responsible for building a crucial cell wall component (ergosterol) in fungi. By blocking this enzyme, Fluconazole prevents the fungus from forming a normal cell wall, leading to the buildup of abnormal sterols.

2024年2月28日 · Mechanism of Action. Fluconazole interacts with 14-demethylase, a cytochrome P-450 enzyme responsible for catalyzing the conversion of lanosterol to ergosterol. As ergosterol forms a critical part of the fungal cell membrane, fluconazole inhibits the synthesis of ergosterol to increase cellular permeability.

2015年12月31日 · Mechanism of action. Fluconazole is a very selective inhibitor of fungal cytochrome P450 dependent enzyme lanosterol 14-α-demethylase. This enzyme normally works to convert lanosterol to ergosterol, which is necessary for fungal cell wall synthesis.

Fluconazole is a first-generation triazole antifungal medication. It differs from earlier azole antifungals (such as ketoconazole) in that its structure contains a triazole ring instead of an imidazole ring.

Includes Fluconazole indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more.

2025年1月14日 · Mechanism of Action. Fluconazole is a highly selective inhibitor of fungal cytochrome P450 dependent enzyme lanosterol 14-α-demethylase. This enzyme functions to convert lanosterol to ergosterol.

2020年7月14日 · Mechanism of action of Fluconazole: Fluconazole works like other azoles and is a potent inhibitor of ergosterol biosynthesis through its action on the cytochrome P-450- dependent enzyme, lanosterol 14 -demethylase.

2010年3月2日 · Fluconazole is indicated for the treatment of: Vaginal candidiasis (vaginal yeast infections due to Candida). Oropharyngeal and esophageal candidiasis. In open noncomparative studies of ...

Fluconazole is a fluorine-substituted, bis-triazole antifungal agent. Its mechanism of action, like that of other azoles, involves interruption of the conversion of lanosterol to ergosterol via binding to fungal cytochrome P-450 and subsequent disruption of fungal membranes.

2024年9月23日 · Fluconazole is the drug of choice for treatment of symptomatic candiduria (cystitis, pyelonephritis, fungus balls) caused by fluconazole-susceptible Candida; IV amphotericin B and/or flucytosine is recommended when fluconazole-resistant Candida (e.g., C. glabrata, C. krusei) are likely.