2016年2月5日 · Gilman reagents (organocuprates) perform two reactions that Grignard reagents (and organolithiums) do not: • They perform conjugate additions to α,β unsaturated ketones. • They are effective nucleophiles for S N 2 reactions.

A Gilman reagent is a diorganocopper compound with the formula Li [CuR 2], where R is an alkyl or aryl. They are colorless solids. [citation needed] A conjugated 1,4 addition using a Gilman reagent with an arbitrary R group.

2016年1月29日 · In the 1940’s Iowa chemist Henry Gilman discovered that adding one further equivalent of an organolithium reagent to an organocopper compound resulted in an “organocuprate” reagent, with two Cu–C bonds and is also comprised of a positive counter-ion (lithium in this case).

2024年3月25日 · Gilman reagents undergo a coupling reaction with organochlorides, bromides, and iodides to form a carbon-carbon bond. During the reaction one of the alkyl groups from the Gilman reagent replaces the halogen atom in the organohalide.

2023年9月28日 · Gilman reagent is an organometallic reagent containing lithium (Li), copper (Cu), and two alkyl or aryl groups. The Gilman reagent is also known as lithium dialkylcuprate or lithium diarylcuprate and is represented by R2CuLi.

Gilman reagents, also known as organocuprates, are organometallic compounds containing copper, lithium, and two R groups, which may be alkyl or aryl. They have the general formula of R 2 CuLi and facilitate a wide variety of reactions, which makes them a versatile and essential tool in organic chemistry.

Gilman reagents are organocuprates with a general formula of R 2 CuLi. To be more specific these are lithium dialkylcuprates. You can look at them as “weaker” Grignard or organolithium reagents, meaning they are less reactive but also unique in a few important ways.

Gilman reagent is an organocuprate reagent consisting of lithium, copper, and alkyl group with the molecular formula [R-Cu-R] + Li – (lithium dialkylcuprate). It is used to synthesize new compounds consisting of carbon-carbon bonds from alkyl, aryl, and vinyl halides.

A Gilman Reagent is an organometallic reagent containing two R-groups (alkyl or aryl), copper, and lithium. The general formula of Gilman reagents can be expressed as R2CuLi. Unlike Grignard reagents, these compounds tend to replace the halide group with an R group when reacted with organic halides.

Gilman reagent, another name for organocopper compounds used for carbon-carbon bond formation in organic synthesis. Compounds of this type were first described in the 1930s by the American chemist Henry Gilman, for whom they are named.