In organometallic chemistry, organolithium reagents are chemical compounds that contain carbon – lithium (C–Li) bonds. These reagents are important in organic synthesis, and are frequently used to transfer the organic group or the lithium atom to the substrates in synthetic steps, through nucleophilic addition or simple deprotonation. [1] .

2023年1月23日 · Organometallic Reagents as Bases. These reagents are very strong bases (pKa's of saturated hydrocarbons range from 42 to 50). Although not usually done with Grignard reagents, organolithium reagents can be used as strong bases. Both Grignard reagents and organolithium reagents react with water to form the corresponding hydrocarbon.

2015年11月9日 · In this post we’ll talk about how certain types of organometallic compounds are made – specifically organolithium and Grignard reagents. Quick summary: Let’s start with organolithium reagents because they’re the simplest. Table of Contents. Organolithium Reagents As Carbanions (The Conjugate Bases Of R-H)

2019年8月2日 · 该类氨基锂代表试剂有 LDA (Lithium diisopropylamide)、LiTMP (Lithium 2,2,6,6-tetramethylpiperidide)、LHMDS (Lithium hexamethyldisilazide)。 ※另外，作为亲核试剂使用的时候，可以转化成 銅锂配合物 (R 2 CuLi) 、该试剂的碱性被有效抑制，而其亲核性不变，可以一哦那个与亲核加成或取代反应。 锂试剂比较hard，与α,β不饱和羰基化合物进行反应的时候、1,2-加成往往优与1,4-加成。 而形成銅锂配合物后，该试剂可以用于1,4-选择性加成反应。 ・ nBuLi …

Simple organolithium reagents (MeLi, PhLi, n-BuLi, sec-BuLi, t-BuLi and a few others) are usually made by the reduction of halides, normally chlorides, with lithium. The direct reaction of lithium metal with more complex substrates is difficult. However, several very effective lithium-arene reagents or catalysts (such as 4,4-di-t-

Organolithium compounds react rapidly with air and water (both vapor and liquid). The reaction with water is the basis of the Gillman double titration method for determining the concentration of organolithium reagents in solution.

2025年1月26日 · This page by Professor Hans Reich (UW-Madison) describes some organolithium reagents commonly used in Organic Chemistry. It also provides the starting compounds as well as typical conditions and references.

Organometallic compounds are amongst the most often used reagents in organic synthesis and organolithium compounds are widely used as very strong bases, nucleophiles and reagents for metallations. The most common members of the alkyllithium family are n-Butyllithium, Methyllithium and tert-Butyllithium and these are widely

An organolithium reagent is an organometallic compound with a direct bond between a carbon and a lithium atom. As the electropositive nature of lithium puts most of the charge density of the bond on the carbon atom, effectively creating a carbanion, organolithium compounds are extremely powerful bases and nucleophiles.

An organolithium reagent is an organometallic compound with a direct bond between a carbon and a lithium atom. As the electropositive nature of lithium puts most of the charge density of the bond on the carbon atom, effectively creating a carbanion, organolithium compounds are extremely powerful bases and nucleophiles.