2019年6月18日 · Ljiljana - If we talk about the synthetic ones, there is the one that was made recently, relatively recently, 2014 in Zürich, and it's called PG5 and it's a polymer generation five. It's a huge branched polymer that has 17 million atoms.

Primary Papers. Jicha GA, Weaver C, Lane E, Vianna C, Kress Y, Rockwood J, Davies P.cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease.

Review of valiltramiprosate (ALZ-801) for the treatment of Alzheimer's disease: a novel small molecule with disease modifying potential. Expert Opin Pharmacother. 2024 May;25(7):791-799. Epub 2024 May 30 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or ...

ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases. Nat Commun. 2024 Nov 11;15(1):9690. PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.

2024年11月9日 · Speakers discussed new small-molecule and antibody therapies, combination approaches, new plasma biomarkers for tau and TDP43, and a good smattering of basic biology, from cellular resilience to microglial diversity. Follow along with Alzforum’s conference coverage.

2024年6月3日 · Overview. Name: NX210c Synonyms: HWSGWSS[CSRSC]GOH (brackets represent the disulfide bond) Chemical Name: H-L-tryphophanyl-L-seryl-glycyl-L-tryptophanyl-L-seryl-L-seryl-L-cysteinyl-L-seryl-L-arginyl-L-seryl-L-cysteinyl-glycyl-OH (disulfide bond) Therapy Type: Small Molecule Target Type: Other Condition(s): Amyotrophic Lateral Sclerosis, …

2014年10月10日 · The AT8 and PG5 antibodies, specific for different hyperphosphorylated forms of tau, detected their targets no earlier than six months, and thioflavin S bound tau fibrils by nine months. However, the biosensor cells picked up tau seeds in 1½-month old mouse brains, consistent with the idea that seeds precede the development of tauopathy.

2025年1月10日 · This expanded picture of a role for p-tau as an innate immune effector molecule with potent activity against HSV-1 is consistent with the antimicrobial protection hypothesis (Moir et al., 2018), which proposed Aβ deposition as an innate immune response to invading pathogens. The results of this current work extend this idea to more concretely ...

SHMT2 Mediates Small-Molecule-Induced Alleviation of Alzheimer Pathology Via the 5'UTR-dependent ADAM10 Translation Initiation. Adv Sci (Weinh). 2024 Mar;11(11):e2305260. Epub 2024 Jan 6 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.

2024年8月5日 · In September 2023, VG-3927 became the first small-molecule TREM-2 agonist cleared to enter the clinic. In October 2023, the first volunteer was treated in a Phase 1, placebo-controlled, single- and multiple-ascending-dose safety study being conducted in Miami.