2022年9月12日 · Bilirubin is an important metabolite of heme (ferroprotoporphyrin IX), a coordination complex coordinating iron in various proteins. It is a potentially toxic substance. However, the body has developed mechanisms for its safe detoxification and disposition.

2023年7月16日 · Bilirubin is metabolised prior to excretion through the faeces and urine. In this article, we will explore the different types of bilirubin, the process of enteric bilirubin metabolism, and we will briefly explore the relevance of bilirubin to clinical practice.

Bilirubin is the terminal product of heme metabolism. Heme is present in hemoglobin and in other oxidative compounds such as hepatic mitochondrial and microsomal cytochromes (P-450). Thus plasma bilirubin is part erythropoietic and part non-erythropoietic.

Metabolic Pathway for Bilirubin in the Hepatocyte. Bilirubin-G corresponds to bilirubin glucuronate; the donor is uridine diphosphate glucuronic acid (UDP-GA). This is catalyzed by the enzyme uridine diphosphate-glucuronyltransferase (UGT1A1).

Find Bilirubin stock images in HD and millions of other royalty-free stock photos, illustrations and vectors in the Shutterstock collection. Thousands of new, high-quality pictures added every day.

2023年9月5日 · Bilirubin is the catabolic product of heme metabolism. Within the physiologic range, bilirubin has cytoprotective and beneficial metabolic effects, but at high levels it is potentially toxic. Fortunately, there are elaborate physiologic …

Emerging evidence suggests total serum bilirubin levels are inversely related to the prevalence of metabolic syndrome including NAFLD. We investigated the effects of bilirubin on all-cause and...

Bilirubin is a yellowish pigment found in several tissues including the blood, liver, and gastrointestinal tract. In the blood, degenerating red blood cells release heme, which is metabolized by macrophages into unconjugated bilirubin. Unconjugated bilirubin travels in the blood bound to albumin until it reaches the liver.

Bilirubin is a yellowish pigment found in several tissues including the blood, liver, and gastrointestinal tract. In the blood, degenerating red blood cells release heme, which is metabolized by macrophages into unconjugated bilirubin. Unconjugated bilirubin travels in the blood bound to albumin until it reaches the liver.

2024年10月10日 · Bilirubin Metabolism. Bilirubin metabolism reflects the body’s ability to modify and manage cellular byproducts. Once bilirubin reaches the intestines, it encounters a diverse microbiome, a community of microorganisms that play a role in its transformation. Intestinal bacteria act upon conjugated bilirubin, converting it into urobilinogen ...