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Carnitine is a quaternary ammonium compound involved in metabolism in most mammals, plants, and some bacteria. In support of energy metabolism, carnitine transports long-chain fatty acids from the cytosol into mitochondria to be oxidized for free energy production, and also participates in removing products of … 展开
The primary biological functions of carnitine in humans include the following:
• fatty acid transport across the mitochondrial membrane by … 展开Carnitine deficiency is rare in healthy people without metabolic disorders, indicating that most people have normal, adequate levels of carnitine normally produced through fatty … 展开
The form present in the body is l-carnitine, which is also the form present in food. Food sources rich in l-carnitine are animal products, particularly beef and pork. Red meats tend to have higher … 展开
Levocarnitine was approved by the U.S. Food and Drug Administration as a new molecular entity under the brand name Carnitor on December 27, 1985. 展开
Chemical properties
Carnitine is a zwitterion, meaning it has both positive and negative charges in its structure. In an aqueous … 展开Pharmacokinetics
The plasma half-life of L-carnitine taken as a supplementation is approximately 17.4 hours. 展开Carnitine interacts with pivalate-conjugated antibiotics such as pivampicillin. Chronic administration of these antibiotics increases the excretion of pivaloyl-carnitine, which … 展开
CC-BY-SA 许可证中的维基百科文本 CARNITINE TRANSPORT AND FATTY ACID OXIDATION - PMC
Carnitine forms a high-energy ester bond with long chain fatty acids by the action of carnitine palmitoyl transferase 1 (CPT-1), located in the inner aspect of the outer mitochondrial …
Carnitine transport and fatty acid oxidation - ScienceDirect
2016年10月1日 · The carnitine cycle in fatty acid oxidation. Fatty acids bound to albumin are transferred across the plasma membrane by the action of fatty acid transport proteins (FATP), …
Carnitine transport and fatty acid oxidation - PubMed
Carnitine is essential for the transfer of long-chain fatty acids across the inner mitochondrial membrane for subsequent β-oxidation. It can be synthesized by the body or assumed with the …
Carnitine, Acylcarnitines and β-Oxidation of Fatty Acids - LIPID MAPS
Carnitine acyltransferases are a family of enzymes responsible for production of acylcarnitines, and among them, they have specificities that cover fatty acids differing in chain-length, …
The role of carnitine in normal and altered fatty acid metabolism
2003年4月1日 · The growing body of evidence about carnitine function has led to increased understanding and identification of disorders associated with altered carnitine metabolism. …
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The role of carnitine in normal and altered fatty acid …
Carnitine is a low-molecular-weight compound obtained from the diet that also is biosynthesized from the essential amino acids lysine and methionine. Carnitine has been identified in a variety of mammalian tissues and has an obligate role …
The Role of Carnitine in Enhancing Physical Performance
The first well-documented function of carnitine was found to be facilitation of the transport of long-chain fatty acids into the matrix of the mitochondrion, which is the site for beta-oxidation. Fatty …
L-carnitine--metabolic functions and meaning in humans life
L-Carnitine is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. L-Carnitine can …
Carnitine is a low-molecular-weight compound obtained from the diet that also is biosynthesized from the essential amino acids lysine and methionine. Carnitine has been identified in a …
